my account
Login
  Loading... Please wait...

Product Details

LYS6K2 | S6K inhibitor

LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2 LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2 Cell permeable.

References/Citations
1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47
2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441

swipe
LYS6K2 | 1082949-67-4 | Structure | Supplier

Catalog#  10-1395

$75.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
1082949-67-4
Catalog Number:
10-1395
Activity:
S6K inhibitor
Chemical Name:
4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
Molecular Weight:
445.42
Molecular Formula:
C21H19F4N7
Solubility:
Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
Physical Properties:
Yellow solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 3 years as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the LYS6K2 | S6K inhibitor to your wish list.