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Lysophosphatidic acid (Oleyl form) | Endogenous LPA receptor agonist

Lysophosphatidic acid (22556-62-3) is a multifunctional intercellular bioactive phospholipid.1 Stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes among others.1 Acts as a proliferative and anti-apoptotic factor.2 Lysophophatidic acid is an agonist at LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors.3 LPA-primed astrocytes induce axonal outgrowth of cortical progenitors.4

References/Citations
1) Moolenaar et al. (1995), Lysophosphatidic acid, a multifunctional phospholipid messenger; J. Biol. Chem., 270 12949
2) Levine et al. (1997), Lysophosphatidic acid; a novel growth and survival factor for renal proximal tubular cells; Am. J. Physiol., 273 F575
3) Goetzl and An (1998), Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate; FASEB J., 12 1589
4) Spohr et al. (2014), LPA-primed astrocytes induce axonal outgrowth of cortical progenitors by activating PKA signaling pathways and modulating extracellular matrix proteins; Front Cell Neurosci., 8 296

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Lysophosphatidic acid | 22556-62-3 | Structure | Supplier

Catalog#  10-1449

$55.00
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CAS:
22556-62-3
Catalog Number:
10-1449
Activity:
Endogenous LPA receptor agonist
Alternate Names:
LPA Na; 1-Oleoyl-lysophosphatidic acid, sodium salt
Chemical Name:
1-Oleoyl-2-hydroxy-sn-glycerol-3-phosphate, sodium
Molecular Weight:
458.51
Molecular Formula:
C21H40O7P
Solubility:
Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
Physical Properties:
white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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