Enhances mitochondrial fusion without interfering with endoplasmic reticulum (ER) and lysosome morphology.1 M-1 protects cells from mitochondrial fragmentation-associated cell death.2 Promotion of mitochondrial fusion has protective effects in rotenone-induced neurotoxicity.3 Cell permeable.
1) Andreaux et al. (2013), Pharmacological approaches to restore mitochondrial function; Nature Rev. Drug Disc., 12 465
2) Yang et al. (2015), Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA; Cell Mol. Life Sci., 72 2585
3) Peng et al. (2016), The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1a Regulates Rotenone-Induced Dopaminergic Neurotoxicity; Mol. Neurobiol., epub ahead of print