M606 | MYC inhibitor

CAS:
 298230-09-8
Catalog Number:
 10-4952
M606 chemical structure

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M606 (298230-09-8) is a cell permeable iron chelator that reduced MYCN mRNA and protein levels in BE(2)-C neuroblastoma cells as well as c-MYC protein levels in HepG2 human hepatoblastoma cells. It also significantly increased HIF1A levels in HepG2 cells independently from MYCN effects. M606 modulated glucose metabolism and inhibited TCA cycle activity in neuroblastoma cells. MYCN downregulation occurs via interaction of M606 with the activating transcription factor E2F3.

References/Citations:

  1. Pandher et al. (2025), The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response; Proc. Natl. Acad. Sci. USA, 122 e2420011122
298230-09-8, M-606, M606, M606 MYC, M606 supplier, Myc inhibitor
CAS:
298230-09-8
Catalog Number:
10-4952
Activity:
MYC inhibitor
Chemical Names:
5-Methoxymethyl-7-(4-methylpiperidin-1-ylmethyl)quinolin-8-ol
Molecular Weight:
300.40
Molecular Formula:

C18H24N2O2

Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Light brown solid
Purity:

>95% TLC/NMR
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ room temperature. Solutions in DMSO may be stored at -20°C for up to 1 month. Product is hygroscopic.
Shipping Code:
RT

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M606 (298230-09-8) is a cell permeable iron chelator that reduced MYCN mRNA and protein levels in BE(2)-C neuroblastoma cells as well as c-MYC protein levels in HepG2 human hepatoblastoma cells. It also significantly increased HIF1A levels in HepG2 cells independently from MYCN effects. M606 modulated glucose metabolism and inhibited TCA cycle activity in neuroblastoma cells. MYCN downregulation occurs via interaction of M606 with the activating transcription factor E2F3.

References/Citations:

  1. Pandher et al. (2025), The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response; Proc. Natl. Acad. Sci. USA, 122 e2420011122

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