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Matrine | Induces RIP3-dependent necroptosis

Matrine (519-02-8) is a natural product found in the plant Sophora flavescens.  It has been found to possess myriad biological activities including a positive inotropic effect1,2, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP723, various anti-cancer effects4,5,6.  Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.7

References/Citations

1) Zhou et al. (2008), Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT; Biol. Pharm. Bull. 31 2057
2) Zhou et al. (2014), The alkaloid matrine of the root of Sophora flavescens prevents arrhythmogenic effect of ouabain; Phytomedicine 21 931
3) Zheng et al. (2015), Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target; Br. J. Pharmacol. 172 4303
4) Li et al. (2010), Therapeutic effects of matrine on primary and metastatic breast cancer; Am. J. Chin. Med. 38 1115
5) Li et al. (2015), Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2; Int. J. Clin. Exp. Pathol. 8 14793
6) Zhou et al. (2014), Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor; Mol. Cancer 13 Issue 59
7) Xu et al. (2017), Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells; Cell Death Discov. 23 16096

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Catalog#  10-4612-0010

$30.00
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CAS:
519-02-8
Catalog Number:
10-4612
Activity:
Induces RIP3-dependent necroptosis
Chemical Name:
(7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3’,2’,1’-ij][1,6]napthyridin-10-one
Source:
Isolated from Sophora flavescens
Molecular Weight:
248.36
Molecular Formula:
C15H24N2O
Solubility:
Soluble in Water (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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