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Product Details

MCI-186 | Antioxidant-nonphenolic

MCI-186 (89-25-8), also known as edaravone,  is an antioxidant free radical scavenger used as a neuroprotective agent following acute brain ischemia and subsequent cerebral infarction.1,2 MCI-186 also protects against MPTP-induced neurotoxicity in the Substantia Nigra.3

References/Citations
1) Watanabe et al. (1994), Protective effects of MCI-186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant actions; J. Pharmacol. Exp. Ther., 268 1597
2) Yoshida et al. (2006) Neuroprotective effects of edaravone:a novel free radical scavenger in cerebrovascular injury; CNS Drug Reviews, 12 9
3) Kawasaki et al. (2007) Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity in the Substantia Nigra but Not the Striatum; J. Pharmacol. Exp. Ther., 322 274

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Focus Biomolecules cell signaling reagent supplier, chemical structure of MCI-186 | Antioxidant-nonphenolic | CAS 89-25-8

Catalog#  10-2295-0050

$35.00
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CAS:
89-25-8
Catalog Number:
10-2295
Activity:
Antioxidant-nonphenolic
Alternate Names:
Edaravone
Chemical Name:
3-Methyl-1-phenyl-2-pyrazolin-5-one
Molecular Weight:
174.2
Molecular Formula:
C10H10N2O
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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