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Product Details

MDL-28170 | Calpain inhibitor

MDL-28170 (88191-84-8) is a potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrauma rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.4

References/Citations
1) Chard et al. (1995), Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases; Neuroscience, 65 1099
2) Li et al. (1998), Postischemic treatment with calpain inhibitor MDL28170 ameliorates brain damage in a gerbil model of global ischemia; Neurosci. Lett., 247 17
3) Thompson et al. (2010), A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model; J. Neurotrauma, 27 2233
4) Chatterjee et al. (1998), D-amino acid containing, high-affinity inhibitors of recombinant human calpain I; J. Med. Chem., 41 2663

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Catalog#  10-3005-0005

$40.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
88191-84-8
Catalog Number:
10-3005
Activity:
Calpain inhibitor
Chemical Name:
N-Benzyloxycarbonylvalylphenylalaninal
Alternate Name:
Z-Val-Phe-CHO; Calpain Inhibitor III
Molecular Weight:
382.45
Molecular Formula:
C22H26N2O4
Solubility:
Soluble in DMSO (up to 75 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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