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Memantine HCl | NMDA antagonist / Anti-Alzheimer's

Memantine HCl (CAS 41100-52-1) is an NMDA noncompetitive, low affinity, open channel blocker, IC50~1 mM at   -60 mV in rat retinal ganglion cells.1 Displays neuroprotective effects in excitotoxic conditions.2 Preferentially blocks excessive NMDA receptor activity without disrupting normal activity.3 A clinically well tolerated drug with therapeutic potential in numerous CNS degenerative disorders.4 In clinical use for Alzheimer’s disease.5


1) Chen and Lipton (1997), Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism; J. Physiol. 499 27
2) Chen et al. (1998), Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term poptentiation; Neuroscience 86 1121
3) Lipton et al. (2005), The molecular basis of memantine action in Alzheimer’s disease and other neurologic disorders: low-affinity, uncompetitive antagonism; Curr. Alzheimer. Res. 2 155
4) Parsons et al. (1999), Memantine is a clinicall well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist—a review of preclinical data; Neuropharmacology 38 735
5) Witt et al. (2004), Memantine hydrochloride; Nat. Rev. Drug Discov. 3 109

Focus Biomolecules reagent supplier, chemical structure Memantine HCl | NMDA antagonist | Anti-Alzheimer's | CAS 41100-52-1

Catalog#  10-2346-0050

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Catalog Number:
NMDA antagonist / Anti-Alzheimer's
Chemical Name:
3,5-Dimethyl-tricyclo[,7]decam-1-amine HCl
Alternate Names:
3,5-Dimethyl-tricyclo[,7]decam-1-amine HCl
Molecular Weight:
Molecular Formula:
C12H21N • HCl
Soluble in Water (up to 20 mg/ml)
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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