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Product Details

Methoprene Acid | Selective RXR agonist

Methoprene Acid (53093-52-7) is an analog of insect juvenile hormone which acts as an insect growth regulator. Binds directly and selectively to the retinoid X receptor (RXR) acting as a transcriptional activator in both insect and mammalian cells with no activity at RAR.1 Negatively regulates thrombosis and hemostasis.2 Induces neurosteroid biosynthesis in human glial GI-1 cells.3 Increases the expression of the brown-fat-uncoupling-protein-1 gene (ucp-1).4


1) Harmon et al. (1995), Activation of mammalian retinoid X receptors by the insect growth regulator methoprene; Proc. Natl. Acad. Sci. USA, 92 6157
2) Unsworth et al. (2017), RXR Ligands Negatively Regulate Thrombosis and Hemostasis; Arterioscler. Thromb. Vasc. Biol., 37 812
3) Kushida and Tamura (2009), Retinoic acids induce neurosteroid biosynthesis in human glial GL-1 cells via the induction of steroidogenic genes; J. Biochem., 146 917
4) Alvarez et al. (2000), Both retinoic-acid-receptor and retinoid-X-receptor-dependent signaling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids; Biochem. J., 345 Pt 1 91

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Catalog#  10-4531-0005

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Catalog Number:
Selective RXR agonist
Molecular Weight:
Molecular Formula:
Soluble in DMSO or Ethanol
Physical Properties:
Colorless oil
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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