METTL16 degrader 15a | METTL16 degrader

CAS:
 2869880-75-9
Catalog Number:
 10-4882
METTL16 Degrader 15a chemical structure

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15a (2869880-75-9) is a METTL16 (RNA methyltransferase-like protein 16) degrader.  It reduced METTL16 protein levels and modulated the PI3K/AKT pathway.  15a inhibited the proliferation of HepG2 cells and induced apoptosis in vitro.  It also inhibited the growth of hepatocellular carcinoma xenografts in mice

References/Citations:

  1. Liu et al. (2025), A novel cinnamic acid derivative for hepatocellular carcinoma therapy by degrading METTL16 protein; Bioorg. Med. Chem. 124 118178
2869880-75-9, Compound 15a, Compound 15a METTL16, METTL16 degrader, METTL16 degrader 15a
CAS:
2869880-75-9
Catalog Number:
10-4882
Activity:
METTL16 degrader
Chemical Names:
(2E)-N-[(4-Ethoxyphenyl)methyl]-3-[3-(4-piperidinyl)phenyl]-2-propenamide
Molecular Weight:
364.49
Molecular Formula:

C23H28N2O2

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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15a (2869880-75-9) is a METTL16 (RNA methyltransferase-like protein 16) degrader.  It reduced METTL16 protein levels and modulated the PI3K/AKT pathway.  15a inhibited the proliferation of HepG2 cells and induced apoptosis in vitro.  It also inhibited the growth of hepatocellular carcinoma xenografts in mice

References/Citations:

  1. Liu et al. (2025), A novel cinnamic acid derivative for hepatocellular carcinoma therapy by degrading METTL16 protein; Bioorg. Med. Chem. 124 118178

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