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Microcystin LR | Protein phosphatase PP1 and PP2A inhibitor

Microcystin LR (CAS 101043-37-2) is a  novel freshwater cyanotoxin.1 Tumor promoter. Potent and selective inhibitor of protein phosphatase 2A (PP2A), IC50=0.04 nM.  PP1, IC50=1.7 nM and PP2B are less sensitive and PP2C is not inhibited (up to 4 mM).2 Considered to be cell-impermeable with the exception of hepatocytes which take it up via an organic anion transporter.3

References/Citations

1) Rinehart et al. (1988), Nodularin, microcystin, and the configuration of Adda; J. Am. Chem. Soc., 110 8557
2) Honkanen et al. (1990), Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases; J. Biol. Chem, 265 19401
3) Runnegar et al. (1995), Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters; Toxicol. Appl. Pharmacol., 134 264

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Focus Biomolecules supplier, chemical structure Microcystin LR | Protein phosphatase PP1, PP2A inhibitor | CAS 101043-37-2

Catalog#  10-2719-0100

$60.00
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CAS:
101043-37-2
Catalog Number:
10-2719
Activity:
Protein phosphatase PP1 and PP2A inhibitor
Source:
Isolated from Microcystis aeruginosa, a fresh water cyanobacteria
Molecular Weight:
995.17
Molecular Formula:
C49H74N10O12
Solubility:
Soluble in DMSO, methanol or ethanol
Physical Properties:
Off-white lyophilized solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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