MIF20 | MIF agonist

MIF20 chemical structure

Available Options

Size:PriceQuantity 
10 mg$70.00
50 mg$250.00
Request Quote / Bulk / Custom Size
Product Inquiry

MIF20 (1191288-81-9) is a macrophage inhibitory factor (MIF) agonist (2.5 fold increase in MIF bound to its receptor @ 500 nM).1 It augments MIF-dependent AMPK signaling and limits ischemic cardiac injury. MIF20 protected the heart from ischemia-reperfusion injury via MIF-mediated activation of AMPK.2  It decreased infarct size and preserved systolic function. MIF20 also augments protective metabolic responses by reducing the NADH/NAD ratio leading to a decrease in the accumulation of reactive oxygen species.

References/Citations:

  1. Wang et al. (2013), Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction; Circulation, 128 225
  2. Wang et al. (2024), A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation; Metabolism, 153 155792
1191288-81-9, MIF agonist, MIF20, MIF20 supplier

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

MIF20 (1191288-81-9) is a macrophage inhibitory factor (MIF) agonist (2.5 fold increase in MIF bound to its receptor @ 500 nM).1 It augments MIF-dependent AMPK signaling and limits ischemic cardiac injury. MIF20 protected the heart from ischemia-reperfusion injury via MIF-mediated activation of AMPK.2  It decreased infarct size and preserved systolic function. MIF20 also augments protective metabolic responses by reducing the NADH/NAD ratio leading to a decrease in the accumulation of reactive oxygen species.

References/Citations:

  1. Wang et al. (2013), Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction; Circulation, 128 225
  2. Wang et al. (2024), A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation; Metabolism, 153 155792