MIF20 | MIF agonist

CAS:
 1191288-81-9
Catalog Number:
 10-4393
MIF20 chemical structure

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MIF20 (1191288-81-9) is a macrophage inhibitory factor (MIF) agonist (2.5 fold increase in MIF bound to its receptor @ 500 nM).1 It augments MIF-dependent AMPK signaling and limits ischemic cardiac injury. MIF20 protected the heart from ischemia-reperfusion injury via MIF-mediated activation of AMPK.2  It decreased infarct size and preserved systolic function. MIF20 also augments protective metabolic responses by reducing the NADH/NAD ratio leading to a decrease in the accumulation of reactive oxygen species.

References/Citations:

  1. Wang et al. (2013), Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction; Circulation, 128 225
  2. Wang et al. (2024), A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation; Metabolism, 153 155792
1191288-81-9, MIF agonist, MIF20, MIF20 supplier
CAS:
1191288-81-9
Catalog Number:
10-4393
Activity:
MIF agonist
Chemical Names:
4-(4-(Pyridin-3-yl)-1H-1,2,3-triazol-1-yl)phenol
Molecular Weight:
238.25
Molecular Formula:

C13H10N4O

Solubility:
Soluble in DMSO (3 mg/ml)
Physical Properties:
Olive green solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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MIF20 (1191288-81-9) is a macrophage inhibitory factor (MIF) agonist (2.5 fold increase in MIF bound to its receptor @ 500 nM).1 It augments MIF-dependent AMPK signaling and limits ischemic cardiac injury. MIF20 protected the heart from ischemia-reperfusion injury via MIF-mediated activation of AMPK.2  It decreased infarct size and preserved systolic function. MIF20 also augments protective metabolic responses by reducing the NADH/NAD ratio leading to a decrease in the accumulation of reactive oxygen species.

References/Citations:

  1. Wang et al. (2013), Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction; Circulation, 128 225
  2. Wang et al. (2024), A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation; Metabolism, 153 155792

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