Milbemectin | RDL GABA agonist and Glutamate-gated Cl channel activator

Milbemectin Supplier | CAS 1799297-76-9 | Focus Biomolecules

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5mg$110.00
25mg$440.00
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Milbemectin (1799297-76-9) is an allosteric agonist at the Drosophila RDL GABA receptor.1,2 Also acts as an agonist at glutamate-gated chloride channels in insects.3 Mutations (specifically a G326E substitution) in the glutamate-gated chloride channel 3 (GluCl3) in phytophagous mites abolishes agonist activity resulting in resistance.4 Commercially used as an acaricide.

Refences/Citations:

  1. Nakao et al. (2015), Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor; Pestic. Biochem. Physiol., 120 101
  2. Casida and Durkin (2015), Novel GABA receptor pesticide targets; Pestic. Biochem. Physiol., 121 22
  3. Wolstenholme and Rogers (2005), Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics; Parasitology, 131 Suppl. S85
  4. Mermans et al. (2017), A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agnostic activity of macrocyclic lactones; Pest. Manag. Sci. 73 2413
1799297-76-9, Glutamate-gated chloride channel agonist, milbemectin, Milbemectin supplier, RDL GABA receptor agonist, RDL GABA receptor allosteric agonist
Alternate Name:
Compound 19-S; NSC-382035

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Milbemectin (1799297-76-9) is an allosteric agonist at the Drosophila RDL GABA receptor.1,2 Also acts as an agonist at glutamate-gated chloride channels in insects.3 Mutations (specifically a G326E substitution) in the glutamate-gated chloride channel 3 (GluCl3) in phytophagous mites abolishes agonist activity resulting in resistance.4 Commercially used as an acaricide.

Refences/Citations:

  1. Nakao et al. (2015), Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor; Pestic. Biochem. Physiol., 120 101
  2. Casida and Durkin (2015), Novel GABA receptor pesticide targets; Pestic. Biochem. Physiol., 121 22
  3. Wolstenholme and Rogers (2005), Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics; Parasitology, 131 Suppl. S85
  4. Mermans et al. (2017), A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agnostic activity of macrocyclic lactones; Pest. Manag. Sci. 73 2413