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Mito-TEMPO | Mitochondria targeted antioxidant

CAS:
1334850-99-5
Catalog Number:
10-4100
Activity:
Mitochondria targeted antioxidant
Chemical Name:
(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride
Molecular Weight:
528.06
Molecular Formula:
C29H35N2O2ClP H2O
Solubility:
Soluble in DMSO (up to 25 mg/ml), in Water (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Physical Properties:
Pale orange solid
Purity:
98% by TLC
HR Mass Spec. (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied
Shipping Code:
RT

Mito-TEMPO (1334850-99-5) is a mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery.1 Resolves mitochondrial oxidative stress and rescues coronary collateral growth in Zucker obese fatty rats.2 Protects mitochondrial membrane potential and attenuates reperfusion-induced ROS production in a mouse ventricular myocyte model.3 Abrogates the induction of senescence in a human vascular smooth muscle cell model.4

References/Citations:

1) Liang et al. (2010) SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery; Free Radic. Biol. Med. 49 1550
2) Pung et al. (2012) Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats; Arterioscler. Thromb. Vasc. Biol. 32 325
3) DeSantiago et al. (2013) Ischemia/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity; Stem Cells Dev. 22 2497
4) Mistri et al. (2013) A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells; Redox. Biol. 1 411

Mito-TEMPO | Mitochondria targeted antioxidant is also available in the Cellular Metabolism Library.
CAS:
1334850-99-5
Catalog Number:
10-4100
Activity:
Mitochondria targeted antioxidant
Chemical Name:
(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride
Molecular Weight:
528.06
Molecular Formula:
C29H35N2O2ClP H2O
Solubility:
Soluble in DMSO (up to 25 mg/ml), in Water (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Physical Properties:
Pale orange solid
Purity:
98% by TLC
HR Mass Spec. (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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