MitoBloCK-12 | Mitochondrial import inhibitor

CAS:
522-51-0
Catalog Number:
10-1525
Activity:
Mitochondrial import inhibitor
Chemical Name:
1,1’-Decamethylenebis(4-aminoquinaldinium)dichloride
Alternate Name:
Dequalinium chloride; MB12; DECA
Molecular Weight:
527.58
Molecular Formula:
C30H40Cl2N4
Solubility:
Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 1 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
50 mg$40.00
250 mg$130.00

MitoBloCK-12 (522-51-0) attenuates mitochondrial protein import (4-10 μM). Discovered in a screen of FDA-approved drugs. Blocks translocation of a mutant form of alanine: glyoxylate aminotransferase (AGT) to the mitochondria and restores AGT trafficking to peroxisomes.1 Also reduces oxalate accumulation and thus has potential to treat patients with primary hyperoxaluria 1 who possess mutations in AGT.1 Also displays antimicrobial activity2, inhibits apamin-sensitive K+ channels3 and induces apoptosis by inhibiting XIAP4.

References/Citations:

1) Miyata et al. (2014), Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1; Proc. Natl. Acad. Sci. USA 111 14406
2) Frey Tirri et al. (2011), Antimicrobial topical agents used in the vagina; Curr. Probl. Dermatol. 40 36
3) Castle et al. (1993), Dequalinium: a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle; Eur. J. Pharmacol. 236 201
4) Orzaez et al. (2011), Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain; Apoptosis 16 460

CAS:
522-51-0
Catalog Number:
10-1525
Activity:
Mitochondrial import inhibitor
Chemical Name:
1,1’-Decamethylenebis(4-aminoquinaldinium)dichloride
Alternate Name:
Dequalinium chloride; MB12; DECA
Molecular Weight:
527.58
Molecular Formula:
C30H40Cl2N4
Solubility:
Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 1 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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