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Product Details

MitoBloCK-6 | Mitochondrial import inhibitor

MitoBloCK-6 inhibits redox-regulated protein translocation into mitochondria. It attenuates the import of Erv1 substrates by inhibition of Erv1 oxidase activity (the import of Tim23 and AAC was decreased by ~50% at 20 μM). MitoBloCK-6 elucidated an unexpected role for Erv1 in the carrier import pathway, namely transferring substrates from the translocase of the outer membrane complex into the small Tim complexes. It impaired cardiac development in zebrafish embryos and induced apoptosis via the release of cytochrome c in human embryonic stem cells but not differentiated cells1.

References/Citations
1) Dabir et al. (2013), A small molecule inhibitor of redox-regulated protein translocation into mitochondria; Dev. Cell, 25 81

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Focus Biomolecules supplier, chemical structure of MitoBloCK-6 | Mitochondrial import inhibitor | CAS 303215-67-0

Catalog#  10-1472

$60.00
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CAS:
303215-67-0
Catalog Number:
10-1472
Activity:
Mitochondrial import inhibitor
Chemical Name:
2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol
Molecular Weight:
357.24
Molecular Formula:
C19H14Cl2N2O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 6 mg/ml with warming).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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