Mitoguazone 2HCl | Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
NMR (Confirms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $70.00 | ||
| 50 mg | $260.00 |
Mitoguazone (7059-23-6) is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2 SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3 Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been examined as a potential anti-cancer treatment because of its ability to inhibit polyamine synthesis.6
References/Citations:
1) Wiliams et al., (1971), Methylglyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases; Biochem. Biophys. Res. Commun., 46 288
2) Corti et al., (1974), Specific inhibition of enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances; Biochem. J., 139 351
3) Williams-Ashman and Seidenfeld, (1986), Aspects of the biochemical pharmacology of methylglyoxal bis(guanylhydrazone); Biochem. Pharmacol., 35 1217
4) Janne and Morris, (1984), Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation; Biochem. J., 218 947
5) Pegg et al., (1985) Induction of spermidine/spermine N-acetyltransferase by methylglyoxal bis(guanylhydrazone); Biochim. Biophys. Acta, 842 111
6) Porter and Janne (2012) Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis. In Inhibition of polyamine metabolism: Biological Significance and Basis for new Therapies; McCann, Ed.; Elsevier; pp.203-248
NMR (Confirms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Mitoguazone (7059-23-6) is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2 SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3 Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been examined as a potential anti-cancer treatment because of its ability to inhibit polyamine synthesis.6
References/Citations:
1) Wiliams et al., (1971), Methylglyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases; Biochem. Biophys. Res. Commun., 46 288
2) Corti et al., (1974), Specific inhibition of enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances; Biochem. J., 139 351
3) Williams-Ashman and Seidenfeld, (1986), Aspects of the biochemical pharmacology of methylglyoxal bis(guanylhydrazone); Biochem. Pharmacol., 35 1217
4) Janne and Morris, (1984), Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation; Biochem. J., 218 947
5) Pegg et al., (1985) Induction of spermidine/spermine N-acetyltransferase by methylglyoxal bis(guanylhydrazone); Biochim. Biophys. Acta, 842 111
6) Porter and Janne (2012) Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis. In Inhibition of polyamine metabolism: Biological Significance and Basis for new Therapies; McCann, Ed.; Elsevier; pp.203-248
Related products
-
MK-571 | Cys LT1 antagonist
From $60.00CAS:115104-28-4Catalog Number:10-1039Activity:Cys LT1 antagonistAlternate Names:L-660711Chemical Name:5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acidMolecular Weight:515.09Molecular Formula:C26H27ClN2O3S2Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:95% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
AG-1296 | PDGFR kinase inhibitor
From $60.00CAS:146535-11-7Catalog Number:10-1087Activity:PDGFR kinase inhibitorChemical Name:6,7-Dimethoxy-3-phenylquinoxalineMolecular Weight:266.3Molecular Formula:C16H14N2O2Solubility:Soluble in DMSO.Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
17-AAG | HSP90 inhibitor
From $35.00CAS:75747-14-7Catalog Number:10-1097Activity:HSP90 inhibitorChemical Name:17-(Allylamino)-17-desmethoxygeldanamycinMolecular Weight:585.7Molecular Formula:C31H43N3O8Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml).Physical Properties:Purple or dark red solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
20% OFF
For Postdoc
Customers!
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.