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Mitoguazone 2HCl | Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor

Mitoguazone (31959-87-2) is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2 SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3 Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been looked at as a potential anti-cancer treatment because of it's ability to inhibit polyamine synthesis.6

References/Citations
1) Wiliams et al., (1971), Methylglyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases; Biochem. Biophys. Res. Commun., 46 288
2) Corti et al., (1974), Specific inhibition of enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances; Biochem. J., 139 351
3) Williams-Ashman and Seidenfeld, (1986), Aspects of the biochemical pharmacology of methylglyoxal bis(guanylhydrazone); Biochem. Pharmacol., 35 1217
4) Janne and Morris, (1984), Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation; Biochem. J., 218 947
5) Pegg et al., (1985) Induciton of spermidine/spermine N-acetyltransferase by methylglyoxal bis(guanylhydrazone); Biochim. Biophys. Acta, 842 111
6) Porter and Janne (2012) Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis. In Inhibition of polyamine metabolism: Biological Significance and Basis for new Therapies; McCann, Ed.; Elsevier; pp.203-248

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Focus Biomolecules, structure Mitoguazone 2HCl | Polyamine biosynthesis / SAM decarboxylase inhibitor | CAS 31959-87-2

Catalog#  10-4552

$70.00
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CAS:
31959-87-2
Catalog Number:
10-4552
Activity:
Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
Alternate Names:
MGBG
Chemical Name:
Methylglyoxal bis(guanylhydrazone) dihydrochloride
Molecular Weight:
257.13
Molecular Formula:
C5H12N8 2HCl
Solubility:
Soluble in Water (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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