Mitoquinone | Mitochondria-targeted antioxidant
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $240.00 |
Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer’s disease.2 Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable. Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available.
References/Citations:
1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674
2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703
3) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873
4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation]
5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation]
6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation]
7) Deng et al. (2019), Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule; J. Clin. Invest., 129 5033 [Focus Citation]
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer’s disease.2 Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable. Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available.
References/Citations:
1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674
2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703
3) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873
4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation]
5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation]
6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation]
7) Deng et al. (2019), Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule; J. Clin. Invest., 129 5033 [Focus Citation]
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