Mitoquinone mesylate | Mitochondria-targeted antioxidant

Mitoquinone mesylate (845959-50-4) is a mitochondria-targeted antioxidant.  Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer’s disease.2,3 Protects pancreatic β-cells against oxidative stress and improves insulin secretion.4 Inhibits respiratory syncytial virus (RSV) production via lowering of mitochondrial ROS levels.5 Cell permeable.

References/Citations for Mitoquinone mesylate

  1. Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674
  2. McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; Neurosci., 31 15703
  3. Young and Franklin, (2019), The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice; Cell Neurosci. 101 103409
  4. Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic b-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873
  5. MengJie et al. (2019), Subversion of Host Cell Mitochondria by RSV to Favor Virus Production in Dependent on Inhibition of Mitochondrial Complex I and ROS Generation; Cells 8 1417
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
845959-50-4
Catalog Number:
10-3914
Chemical Name:

10-(6’-Ubiquinonyl)decyltriphenylphosphonium mesylate

Molecular Weight:
678.82
Molecular Formula:
C37H44O4P ∙ CH3SO3
Solubility:
Soluble in DMSO.
Physical Properties:
Orange waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Mitoquinone mesylate | Mitochondria-targeted antioxidant

$70.00$240.00

CAS:
845959-50-4
Catalog Number:
10-3914
Chemical Name:

10-(6’-Ubiquinonyl)decyltriphenylphosphonium mesylate

Molecular Weight:
678.82
Molecular Formula:
C37H44O4P ∙ CH3SO3
Solubility:
Soluble in DMSO.
Physical Properties:
Orange waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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