MKV3 | Copper-ATPase inhibitor

CAS:
 169120-56-3
Catalog Number:
 10-4898
MKV3 chemical structure

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MKV3 (169120-56-3) is a first-in-class inhibitor of Cu+-ATPases with broad-spectrum activity across bacteria, fungi, plants, and animals.1 In mammalian cells it blocked copper-stimulated ATP7A trafficking, increased copper burden, sensitized cells to copper toxicity, and triggered cuproptosis. It has also been reported to be an allosteric MIF inhibitor.2

References/Citations:

  1. Shanbhag al. (2026), A broad-spectrum inhibitor of copper-exporting P1B-type ATPases; Proc. Natl. Acad. Sci. USA, 123 e2604078123
  2. Pantouris al. (2025), Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia; ACS Omega, 10 17441
169120-56-3, Copper-ATPase inhibitor, Cu-ATPase inhibitor, MKV3, MKV3 supplier
CAS:
169120-56-3
Catalog Number:
10-4898
Activity:
Copper-ATPase inhibitor
Chemical Names:
3-[(2-Chlorophenyl)amino]-2-cyano-3-thioxo-N-[3-(trifluoromethyl)phenyl]propanamide
Molecular Weight:
397.80
Molecular Formula:

C17H11ClF3N3OS

Solubility:
Soluble in DMSO (>60 mg/ml)
Physical Properties:
Pale yellow solid
Purity:

98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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MKV3 (169120-56-3) is a first-in-class inhibitor of Cu+-ATPases with broad-spectrum activity across bacteria, fungi, plants, and animals.1 In mammalian cells it blocked copper-stimulated ATP7A trafficking, increased copper burden, sensitized cells to copper toxicity, and triggered cuproptosis. It has also been reported to be an allosteric MIF inhibitor.2

References/Citations:

  1. Shanbhag al. (2026), A broad-spectrum inhibitor of copper-exporting P1B-type ATPases; Proc. Natl. Acad. Sci. USA, 123 e2604078123
  2. Pantouris al. (2025), Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia; ACS Omega, 10 17441