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Product Details

ML-204 | TRPC4 blocker

ML-204 (5485-86-1) is a selective blocker of TRPC4 channels (IC50 = 0.96 - 2.6 μM, depending on assay). Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5.  Has no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM. A useful tool for exploring the involvement of TRPC and TRPC-like channels in cellular signaling and physiology.2-4

References/Citations

1) Miller et al. (2011), Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels; J. Biol. Chem., 286 33436
2) Zhang et al. (2013), GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons; Neuropharmacology, 72 106
3) Zhang et al. (2016), Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons; Neuroscience, 322 308
4) Zhao et al. (2015), TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Retal Retinal Pigment Epithelium; Invest. Ophthalmol. Vis. Sci., 56 1916
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Catalog#  10-2841-0005

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
5485-86-1
Catalog Number:
10-2841
Activity:
TRPC4 blocker
Chemical Name:
4-Methyl-2-(1-piperidinyl)quinoline
Molecular Weight:
226.32
Molecular Formula:
C15H18N2
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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