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Product Details

ML-241 | p97 AAA ATPase inhibitor

ML241 (1346528-06-0) is a potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3

References/Citations
1) Chou et al. (2013), Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase; Chem. Med. Chem., 8 297
2) Chou et al. (2014) Specific inhibition of p97/VCP ATPase amd kinetic analysis demonstrate interaction between D1 and D2 ATPase domains; J. Mol. Biol. 426 2886
3) Fang et al. (2015) Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex; Chem. Med. Chem. 10 52

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Catalog#  10-1555-0005

$90.00
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CAS:
1346528-06-0
Catalog Number:
10-1555
Activity:
p97 AAA ATPase inhibitor
Chemical Name:
N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine
Alternate Name:
CID49830260
Molecular Weight:
372.46
Molecular Formula:
C23H24N4O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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