ML-SA1 | TRPML activator

CAS:
332382-54-4
Catalog Number:
10-1439
Activity:
TRPML activator
Chemical Name:
2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Molecular Weight:
362.43
Molecular Formula:
C22H22N2O3
Solubility:
Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
10 mg$75.00
50 mg$300.00

ML-SA1 (332382-54-4) is a TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4

References/Citations:

1) Grimm et al. (2010), Small molecule activators of TRPML3; Mol. Chem. Biol., 17 135
2) Shen et al. (2012), Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release; Nature Commun., 3 731
3) Weiss et al. (2012), Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases; Commun. Integer. Biol., 5 111
4) Zou et al. (2015), Reactivation of lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells;J. Neurosci., 35 6801

CAS:
332382-54-4
Catalog Number:
10-1439
Activity:
TRPML activator
Chemical Name:
2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Molecular Weight:
362.43
Molecular Formula:
C22H22N2O3
Solubility:
Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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