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Product Details

ML210 | GPX4 inhibitor / Ferroptosis inducer

ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3

References/Citations

1) Weiwer et al. (2012), Development of small-molecule probes that selectively kill cells induced to express mutant RAS; Bioorg. Med. Chem. Lett. 22 1822
2) Yang et al. (2014), Regulation of Ferroptotic Cancer Cell Death by GPX4; Cell 156 317
3) Viswanathan et al. (2017), Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway; Nature 547 453

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Catalog#  10-4002-0010

$75.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1360705-96-9
Catalog Number:
10-4002
Activity:
GPX4 inhibitor / Ferroptosis inducer
Chemical Name:
(4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
Molecular Weight:
475.32
Molecular Formula:
C22H20Cl2N4O4
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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