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ML300 | SARS-CoV 3CL protease inhibitor

CAS:
N/A
Catalog Number:
10-4961
Activity:
SARS-CoV 3CL protease inhibitor
Chemical Names:
N-(4-(2-(1H-Benzo[d][1,2,3]triazol-1-yl)-N-(thiophen-3-ylmethyl)acetamido)phenyl)cyclopropanecarboxamide
Molecular Weight:
431.51
Molecular Formula:
C23H21N5O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

ML300 is a selective non-covalent inhibitor of SARS-CoV 3CL protease (IC50 = 4.11 µM).1,2

References:

  1. Turlington et al. (2012) Non-covalent triazole-based inhibitors of the SARS main protease 3CLpro; In: Probe Reports from the NIH Molecular Libraries Program
  2. Turlington et al. (2013) Discovery of N-(Benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl)carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding; Bioorg. Med. Chem. Lett. 23 6172
ML300 | SARS-CoV 3CL protease inhibitor is also available in the Cellular Metabolism Library.
CAS:
N/A
Catalog Number:
10-4961
Activity:
SARS-CoV 3CL protease inhibitor
Chemical Names:
N-(4-(2-(1H-Benzo[d][1,2,3]triazol-1-yl)-N-(thiophen-3-ylmethyl)acetamido)phenyl)cyclopropanecarboxamide
Molecular Weight:
431.51
Molecular Formula:
C23H21N5O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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