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Product Details

MLN4924 | NEDD8 activating enzyme inhibitor

MLN4924 (905579-51-3) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor. Disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Supresses the growth of tumor xenografts in mice. Cell permeable.

References/Citations
1) Soucy et al. (2009), An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer; Nature, 458 732
2) Milhollen et al. (2010) MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-(kappa)B-dependent lymphoma; Blood, 116 1515

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Focus Biomolecules cell signaling tech supplier, structure of MLN4924 | NEDD8 activating enzyme inhibitor | CAS 905579-51-3

Catalog#  10-1311-0001

$90.00
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CAS:
905579-51-3
Catalog Number:
10-1311
Activity:
NEDD8 activating enzyme inhibitor
Chemical Name:
((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate
Molecular Weight:
443.53
Molecular Formula:
C21H25N5O4S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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