Size : | Price | Quantity | |
---|---|---|---|
5 mg | $75.00 | ||
25 mg | $220.00 |
Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 μM).2 Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory.3 Enhances regeneration of adult axons.4
References/Citations:
1) Mayer et al. (1999), Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen; Science, 286 971
2) Kapoor et al. (2000), Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of mitotic kinesin, Eg5; J. Cell Biol., 150 975
3) Ari et al. (2014), Alzheimer Aß inhibition of Eg5/kinesin 5 reduces neurotrophin/transmitter receptor function; Neurobiol. Aging, 35 1839
4) Lin et al. (2011), Inhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons; Traffic, 12 269
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Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 μM).2 Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory.3 Enhances regeneration of adult axons.4
References/Citations:
1) Mayer et al. (1999), Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen; Science, 286 971
2) Kapoor et al. (2000), Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of mitotic kinesin, Eg5; J. Cell Biol., 150 975
3) Ari et al. (2014), Alzheimer Aß inhibition of Eg5/kinesin 5 reduces neurotrophin/transmitter receptor function; Neurobiol. Aging, 35 1839
4) Lin et al. (2011), Inhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons; Traffic, 12 269
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