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Monocrotaline | Induces pulmonary fibrosis

Monocrotaline (315-22-0) is a naturally occurring pyrrolizidine alkaloid used to create an animal model of pulmonary arterial hypertension (PAH). It can mimic several important aspects of human PAH including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, production of inflammatory cytokines and right ventricle failure.1  Induces endoplasmic reticulum stress in a rat model of PAH.2 Induces sinusoidal obstruction syndrome, a form of drug-induced liver injury.3 May be used to establish a mouse model of pulmonary fibrosis.4

References/Citations

1) Nogueira-Ferreira et al. (2015), Exploring the monocrotaline animal model for the study of pulmonary aterial hypertension: A network approach; J. Pulm. Pharmacol. Ther., 35 8
2) Wang et al. (2016), Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension; Cardiovasc. Drugs Ther., 30 587
3) Nakamura et al. (2012), Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9; J. Hepatol., 57 1037
4) Hayashi et al. (1995) Establishment of an animal model for pulmonary fibrosis in mice using monocrotaline; Toxicol. Pathol. 23 63

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Catalog#  10-2872

$49.00
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CAS:
315-22-0
Catalog Number:
10-2872
Activity:
Induces pulmonary fibrosis
Chemical Name:
(3R,4R,5R)-4,5,8,10,12,13,13aR,13bR-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
Alternate Names:
Crotaline; MCT; NSC28693
Molecular Weight:
325.36
Molecular Formula:
C16H23NO6
Solubility:
Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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