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Montelukast sodium | Leukotriene antagonist and GPR17 antagonist

Montelukast sodium (151767-02-1) is a potent, selective CysLT1 receptor (leukotriene D4) antagonist (Ki = 0.18 nM).1,2 Displays anti-inflammatory and anti-asthmatic effects. Clinically useful agent for treatment of chronic asthma.3 Attenuates chronic brain injury after focal cerebral ischemia in rodent models.4 Decreases blood brain barrier dysfunction in mouse models.5 Blockade of GPR17 by montelukast elevates neural stem and progenitor proliferation.6


1) Lynch et al. (1999), Characterization of the human cysteinyl leukotriene CysLT1 receptor; Nature, 399 789
2) Jones et al. (1995), Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist; Can. J. Physiol. Pharmacol., 73 191
3) Reiss et al. (1998), Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group; Arch. Intern. Med., 158 1213
4) Zhao et al. (2011), Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats; J. Pharm. Pharmacol., 63 550
5) Lenz et al. (2014), Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction; Neuroscience, 277 859
6) Huber et al. (2011) Inhibition of leukotriene receptors boosts neural progenitor proliferation; Cell Physiol. Biochem., 28 793

Focus Biomolecules supplier, chemical structure of Montelukast sodium | Leukotriene & GPR17 antagonist | CAS 151767-02-1

Catalog#  10-2597-0050

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Catalog Number:
Leukotriene antagonist and GRP17 antagonist
Chemical Name:
2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate, sodium salt
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 60 mg/ml), in Water (up to 30 mg/ml) , or in Ethanol (up to 60 mg/ml)
Physical Properties:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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