Moxidectin | Anthelmintic/YAP-TAZ blocker

CAS:
 113507-06-5
Catalog Number:
 10-4436

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Moxidectin (113507-06-5) is a macrocyclic lactone anthelmintic drug used in veterinary medicine for the treatment of various parasitic diseases. In 2018, It was approved for use in the treatment of river-blindness in humans.1 Moxidectin is also being investigated as a possible treatment for scabies in humans.2 Moxidectin inhibited the proliferation of several glioblastoma multiforme (GBM) cell lines via induction of apoptosis.3 It inhibited the MEK-ERK pathway resulting in blocking of nuclear translocation and transcription of the YAP/TAZ-TEAD complex in GBM cells.  It suppressed growth of GBM tumors by 90% in an intracranial tumor model.

References/Citations:

  1. Maheu-Girous and Joseph (2018), Moxidectin for deworming: from trials to implementation; Lancet Infect. Dis. 18 817
  2. Mounsey7 et al. (2016), Prospects for Moxidectin as a New Oral Treatment for Human Scabies; PLoS Negl. Trop. Dis. 10 e0004389
  3. Kaushik et al. (2025), Moxidectin Unravels the Role of the Hippo-YAP Pathway in Maintaining Immunity of Glioblastoma Multiforme; Mol. Cancer Ther. 24 1156
113507-06-5, Moxidectin, Moxidectin supplier, Moxidectin Yap-Taz blocker
CAS:
113507-06-5
Catalog Number:
10-4436
Activity:
Anthelmintic/YAP-TAZ blocker
Chemical Names:
(1R,4S,4'E,5'S,6R,6'S,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4'-methoxyimino-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
Molecular Weight:
639.83
Molecular Formula:

C37H53NO8

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Moxidectin (113507-06-5) is a macrocyclic lactone anthelmintic drug used in veterinary medicine for the treatment of various parasitic diseases. In 2018, It was approved for use in the treatment of river-blindness in humans.1 Moxidectin is also being investigated as a possible treatment for scabies in humans.2 Moxidectin inhibited the proliferation of several glioblastoma multiforme (GBM) cell lines via induction of apoptosis.3 It inhibited the MEK-ERK pathway resulting in blocking of nuclear translocation and transcription of the YAP/TAZ-TEAD complex in GBM cells.  It suppressed growth of GBM tumors by 90% in an intracranial tumor model.

References/Citations:

  1. Maheu-Girous and Joseph (2018), Moxidectin for deworming: from trials to implementation; Lancet Infect. Dis. 18 817
  2. Mounsey7 et al. (2016), Prospects for Moxidectin as a New Oral Treatment for Human Scabies; PLoS Negl. Trop. Dis. 10 e0004389
  3. Kaushik et al. (2025), Moxidectin Unravels the Role of the Hippo-YAP Pathway in Maintaining Immunity of Glioblastoma Multiforme; Mol. Cancer Ther. 24 1156

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