MRL-24 | PPAR gamma partial agonist

MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. MRL-24 is highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ. Cell permeable.

References/Citations

1) Choi et al. (2010), Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by CDK5;  Nature, 466 451

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

5 mg, 25 mg

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Catalog Number:
10-1365
CAS:
393794-17-7
Activity:
PPARγ partial agonist
Chemical Name:
(S)-2-(3-((1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid
Molecular Weight:
527.49
Molecular Formula:
C28H24F3NO6
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

MRL-24 | PPAR gamma partial agonist

$65.00$260.00

Catalog Number:
10-1365
CAS:
393794-17-7
Activity:
PPARγ partial agonist
Chemical Name:
(S)-2-(3-((1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid
Molecular Weight:
527.49
Molecular Formula:
C28H24F3NO6
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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