MS102 | USP2 inhibitor

CAS:
 N/A
Catalog Number:
 10-4937
MS102 chemical structure

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MS102 is an orally bioavailable derivative (IC50 = 5.46 µM) of the USP2 inhibitor ML364.1  It displayed improved USP2 inhibition efficacy and improved antiviral activity (SARS-CoV-2 HepG2 and Calu-3 cells) compared to ML364.  Antiviral activity of MS102 is via inhibition of the deubquitinase activity of USP2 on ACE2 resulting in reduction of ACE2 levels. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in syngeneic mouse tumor models to enhance T cell response and synergizes with anti-PD-1 immunotherapy.2

References/Citations:

  1. Dang et al. (2023), USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice; Sci. Transl. Med. 15 eadh7668
  2. Chen et al. (2025), Targeted destruction of VISTA boosts anti-tumor immunotherapy; Cell Res. 35 987
MS-102, MS102, MS102 supplier, MS102 USP2 inhibitor, USP2 inhibitor
CAS:
N/A
Catalog Number:
10-4937
Activity:
USP2 inhibitor
Chemical Names:
N-(4-(4-Bromophenyl)thiazol-2-yl)-2-((4-methylphenyl)sulfonamido)-5-(trifluoromethyl)benzamide
Molecular Weight:
596.44
Molecular Formula:

C24H17BrF3N3O3S2

Solubility:
Soluble in DMSO (100 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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MS102 is an orally bioavailable derivative (IC50 = 5.46 µM) of the USP2 inhibitor ML364.1  It displayed improved USP2 inhibition efficacy and improved antiviral activity (SARS-CoV-2 HepG2 and Calu-3 cells) compared to ML364.  Antiviral activity of MS102 is via inhibition of the deubquitinase activity of USP2 on ACE2 resulting in reduction of ACE2 levels. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in syngeneic mouse tumor models to enhance T cell response and synergizes with anti-PD-1 immunotherapy.2

References/Citations:

  1. Dang et al. (2023), USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice; Sci. Transl. Med. 15 eadh7668
  2. Chen et al. (2025), Targeted destruction of VISTA boosts anti-tumor immunotherapy; Cell Res. 35 987

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