MS102 | USP2 inhibitor

MS102 chemical structure

Available Options

Size:PriceQuantity 
5 mg$70.00
25 mg$240.00
Request Quote / Bulk / Custom Size
Product Inquiry

MS102 is an orally bioavailable derivative (IC50 = 5.46 µM) of the USP2 inhibitor ML364.1  It displayed improved USP2 inhibition efficacy and improved antiviral activity (SARS-CoV-2 HepG2 and Calu-3 cells) compared to ML364.  Antiviral activity of MS102 is via inhibition of the deubquitinase activity of USP2 on ACE2 resulting in reduction of ACE2 levels. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in syngeneic mouse tumor models to enhance T cell response and synergizes with anti-PD-1 immunotherapy.2

References/Citations:

  1. Dang et al. (2023), USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice; Sci. Transl. Med. 15 eadh7668
  2. Chen et al. (2025), Targeted destruction of VISTA boosts anti-tumor immunotherapy; Cell Res. 35 987
MS-102, MS102, MS102 supplier, MS102 USP2 inhibitor, USP2 inhibitor

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

MS102 is an orally bioavailable derivative (IC50 = 5.46 µM) of the USP2 inhibitor ML364.1  It displayed improved USP2 inhibition efficacy and improved antiviral activity (SARS-CoV-2 HepG2 and Calu-3 cells) compared to ML364.  Antiviral activity of MS102 is via inhibition of the deubquitinase activity of USP2 on ACE2 resulting in reduction of ACE2 levels. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in syngeneic mouse tumor models to enhance T cell response and synergizes with anti-PD-1 immunotherapy.2

References/Citations:

  1. Dang et al. (2023), USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice; Sci. Transl. Med. 15 eadh7668
  2. Chen et al. (2025), Targeted destruction of VISTA boosts anti-tumor immunotherapy; Cell Res. 35 987