MSA-2 | STING agonist

CAS:
 129425-81-6
Catalog Number:
 10-4141
MSA-2 chemical structure

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MSA-2 (129425-81-6) is a non-nucleotide-based orally available STING agonist.2 The active agent is a non-covalent dimer that forms in solution. It displays substantially higher potency in an acidified tumor microenvironment.1 It reversed anti-PD-1 therapy resistance in cervical cancer.2 MSA-2 displayed efficacy against clear cell renal cell carcinoma3 and enhanced natural killer cells against breast cancer stem cells4.

References/Citations:

  1. Pan et al. (2020), An orally available non-nucleotide STING agonist with antitumor activity; Science 369 eaba6098
  2. Li et al. (2024), STING agonist inflames the cervical cancer immune microenvironment and overcomes ant-PD-1 therapy resistance; Front. Immunol. 15 1342647
  3. Wang et al. (2024), STING agonist, MSA-2. Inhibits clear cell renal cell carcinoma through improving tumor microenvironment; Mol. Cell Biochem. 479 1697
  4. Bushnell et al. (2024), Natural Killer Cell Regulation of Breast Cancer Stem Cells Mediates Metastatic Dormancy; Cancer Res. 84 3337
129425-81-6, MSA-2, MSA-2 supplier, Non-nucleotide STING agonist, STING agonist
CAS:
129425-81-6
Catalog Number:
10-4141
Activity:
STING agonist
Chemical Names:
4-(5,6-Dimethoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid
Molecular Weight:
294.32
Molecular Formula:

C14H14O5S

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:

98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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MSA-2 (129425-81-6) is a non-nucleotide-based orally available STING agonist.2 The active agent is a non-covalent dimer that forms in solution. It displays substantially higher potency in an acidified tumor microenvironment.1 It reversed anti-PD-1 therapy resistance in cervical cancer.2 MSA-2 displayed efficacy against clear cell renal cell carcinoma3 and enhanced natural killer cells against breast cancer stem cells4.

References/Citations:

  1. Pan et al. (2020), An orally available non-nucleotide STING agonist with antitumor activity; Science 369 eaba6098
  2. Li et al. (2024), STING agonist inflames the cervical cancer immune microenvironment and overcomes ant-PD-1 therapy resistance; Front. Immunol. 15 1342647
  3. Wang et al. (2024), STING agonist, MSA-2. Inhibits clear cell renal cell carcinoma through improving tumor microenvironment; Mol. Cell Biochem. 479 1697
  4. Bushnell et al. (2024), Natural Killer Cell Regulation of Breast Cancer Stem Cells Mediates Metastatic Dormancy; Cancer Res. 84 3337

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