MYCMI-11 | MYC:MAX interaction inhibitor

CAS:
 2291360-73-9
Catalog Number:
 10-4146
MYCMI-11 chemical structure

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MYCMI-11 (2291360-73-9) is an inhibitor of the MYC:MAX interaction (IC50 = 6 µM).1 It inhibited the growth of MYCN-amplified neuroblastoma cells.  MYCMI-11 binds to the bHLH-LZ domain of MYC (KD = 24 µM).  Disruption of the MYC:MAX interaction by MYCMI-11 along with 20S proteasome activation with TCH-165 (Focus Cat.#10-4400) enhanced MYC degradation, suppressed MYC-dependent transcription, and promoted apoptosis in colon cancer cells.2

References/Citations:

  1. Castell et al. (2018) A Selective High Affinity MYC-Binding Compound Inhibits MYC:Max Interaction and MYC-Dependent Tumor Cell Proliferation; Sci.  Rep. 8 10064
  2. Olatunde and Tepe (2026) Chemical Induction of MYC Protein Degradation via MYC-MAX Disruption and 20S Proteasome Activation; ACS Chem. Biol. 21 1728
MYC degradation, Myc inhibitor, MYC interaction inhibitor, MYC:MAX interaction inhibitor, MYCMI-11, MYCMI-11 supplier, MYCMI11
CAS:
2291360-73-9
Catalog Number:
10-4146
Activity:
MYC:MAX interaction inhibitor
Chemical Names:
N-Butyl-1-methyl-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Weight:
281.36
Molecular Formula:

C16H19N5

Solubility:
Soluble in DMSO (10 mg/ml with warming)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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MYCMI-11 (2291360-73-9) is an inhibitor of the MYC:MAX interaction (IC50 = 6 µM).1 It inhibited the growth of MYCN-amplified neuroblastoma cells.  MYCMI-11 binds to the bHLH-LZ domain of MYC (KD = 24 µM).  Disruption of the MYC:MAX interaction by MYCMI-11 along with 20S proteasome activation with TCH-165 (Focus Cat.#10-4400) enhanced MYC degradation, suppressed MYC-dependent transcription, and promoted apoptosis in colon cancer cells.2

References/Citations:

  1. Castell et al. (2018) A Selective High Affinity MYC-Binding Compound Inhibits MYC:Max Interaction and MYC-Dependent Tumor Cell Proliferation; Sci.  Rep. 8 10064
  2. Olatunde and Tepe (2026) Chemical Induction of MYC Protein Degradation via MYC-MAX Disruption and 20S Proteasome Activation; ACS Chem. Biol. 21 1728

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