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Mycophenolate mofetil | Immunomodulator

Mycophenolate mofetil (128794-94-5) is a mycophenolic acid prodrug. Immunosuppressive agent useful in prevention of organ allograft rejection.1 Is metabolized to mycophenolic acid in vivo  which acts by inhibiting the biosynthesis of guanine nucleotides via  inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages.2,3 IL-2-dependent T cell proliferation is also inhibited.4  Inhibits microglial and astrocytic activation reducing cell death after neuronal injury.5  Active in vivo.

References/Citations

1) Allison & Eugui (1996), Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF); Clin. Transplant., 10 77
2) Jonsson et al. (2002), Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide, and LDH in macrophages; Cell. Immunol., 216 93
3) Allison et al. (1993), Mechanisms of action of mycophenolic acid; Ann. NY Acad. Sci., 696 63
4) Quemeneur et al. (2002), Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis; J. Immunol., 169 2747
5) Ebrahimi et al. (2012) Time dependent neuroprotection of mycophenolate mofetil; effects on temporal dynamics in glial proliferation, apoptosis, and scar formation; J. Neuroinflammation, 9 89

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Focus Biomolecules supplier, chemical structure of Mycophenolate mofetil | Immunomodulator | CAS 128794-94-5

Catalog#  10-2086

$35.00
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CAS:
128794-94-5
Catalog Number:
10-2086
Activity:
Immunomodulator
Chemical Name:
6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
Molecular Weight:
433.51
Molecular Formula:
C23H31NO7
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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