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Mycophenolic acid | Immunosuppressant

Mycophenolic acid (24280-93-1) is an immunomodulator1 that blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5'-monophosphate dehydrogenase. This in turn suppresses the production of proinflammatory cytokines, nitric oxide and LDH in macrophages2,3. Inhibits IL-2 -dependent T cell proliferation4.

References/Citations
1) Eugui et al. (1991), Lymphocyte-selective cyostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion; Scand. J. Immunol., 33 161
2) Jonsson et al. (2002), Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide and LDH in macrophages; Cell. Immunol., 216 93
3) Allison et al. (1993), Mechanisms of action of mycophenolic acid; Ann. NY Acad. Sci., 696 63
4) Quemeneur et al. (2002), Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis; J. Immunol., 169 2747

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Focus Biomolecules supplier, chemical structure of Mycophenolic acid | Immunosuppressant | CAS 24280-93-1

Catalog#  10-2087

$40.00
Quantity
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CAS:
24280-93-1
Catalog Number:
10-2087
Activity:
Immunosuppressant
Alternate Names:
NSC129185
Chemical Name:
6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexanoic acid
Molecular Weight:
320.35
Molecular Formula:
C17H20O6
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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