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Product Details

N-Acetyl-S-farnesyl-L-cysteine | S-Farnesylcysteine methyl transferase inhibitor

N-Acetyl-S-farnesyl-L-cysteine (AFC) (135304-07-3) inhibits S-farnesylcysteine methyl transferase (Km = 20 µM).1 AFC blocked capacitative Ca2+ influx in human embryonic kidney 293 cells2 and store-regulated Ca2+ entry in human platelets3.  Topical AFC has been shown to inhibit neutrophil chemotaxis and other inflammatory responses without systemic effects.4,5

References/Citations

1) Volker et al. (1991), Effects of farnesylcyteine analogs on protein carboxyl methylation and signal tranduction; J. Biol. Chem. 266 21515
2) Xu et al. (1996), Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol. 50 1495
3) Rosado and Sage (2000), Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J. 347 183
4) Gordon et al. (2008), Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol. 128 643
5) Adhami et al. (2012), N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells; Exp. Dermatol. 21 700

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Catalog#  10-4610-0005

$50.00
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Catalog Number:
10-4610
CAS #:
135304-07-3
Activity:
S-Farnesylcysteine methyl transferase inhibitor
Chemical Name:
2-Acetamido-3-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)propanoic acid
Alternate Names:
AFC
Molecular Weight:
367.55
Molecular Formula:
C20H33NO3S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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