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N-Acetyl-S-farnesyl-L-cysteine | S-Farnesylcysteine methyl transferase inhibitor

N-Acetyl-S-farnesyl-L-cysteine (AFC) (135304-07-3) inhibits S-farnesylcysteine methyl transferase (Km = 20 µM).1 AFC blocked capacitative Ca2+ influx in human embryonic kidney 293 cells2 and store-regulated Ca2+ entry in human platelets3.  Topical AFC has been shown to inhibit neutrophil chemotaxis and other inflammatory responses without systemic effects.4,5


1) Volker et al. (1991), Effects of farnesylcyteine analogs on protein carboxyl methylation and signal tranduction; J. Biol. Chem. 266 21515
2) Xu et al. (1996), Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol. 50 1495
3) Rosado and Sage (2000), Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J. 347 183
4) Gordon et al. (2008), Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol. 128 643
5) Adhami et al. (2012), N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells; Exp. Dermatol. 21 700

Focus Biomolecules cell signaling reagent supplier, chemical structure of N-Acetyl-S-farnesyl-L-cysteine | CAS 135304-07-3

Catalog#  10-4610-0005

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Catalog Number:
CAS #:
S-Farnesylcysteine methyl transferase inhibitor
Chemical Name:
2-Acetamido-3-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)propanoic acid
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Yellow oil
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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