N-Acetylcysteine ethyl ester | Cell permeable antioxidant

N-Acetylcysteine ethyl ester chemical structure Focus Biomolecules

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N-Acetylcysteine ethyl ester (59587-09-6) is a lipophilic, cell permeable ethyl ester derivative of N-acetylcysteine.1  In oxidative stressed retinal pigment epithelial (RPE) cells NACET increases viability more efficiently than NAC and pretreatment predisposes RPE cells to oxidative stress resistance.1 Enhances intracellular glutathione concentration in HUVECs.2 Acts as a potent protector against hydroperoxide-induced oxidative damage.3 Protects against UV-induced reactive intermediates in human keratinocytes.4

References/Citations:

  1. Tosi et al. (2021), Superior Properties of N-Acetylcyteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage; Int. J. Mol. Sci. 22 600
  2. Giustarini et al. (2018), N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs; Free Radic. Biol. Med. 126 202
  3. Giustarini et al. (2012), N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential; Biochem. Pharmacol. 84 1522
  4. Steenvoorden et al. (1997), Cysteine derivatives protect against UV-inducede reactive intermediates in human keratinocytes: the role of glutathione synthesis; Photochem. Photobiol. 66 665
59587-09-6, N-Acetyl-L-cysteine ethyl ester, N-Acetylcysteine ethyl ester, N-Acetylcysteine ethyl ester supplier, NAC ethyl ester, NACET
Alternate Name:
NACET; NAC ethyl ester

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N-Acetylcysteine ethyl ester (59587-09-6) is a lipophilic, cell permeable ethyl ester derivative of N-acetylcysteine.1  In oxidative stressed retinal pigment epithelial (RPE) cells NACET increases viability more efficiently than NAC and pretreatment predisposes RPE cells to oxidative stress resistance.1 Enhances intracellular glutathione concentration in HUVECs.2 Acts as a potent protector against hydroperoxide-induced oxidative damage.3 Protects against UV-induced reactive intermediates in human keratinocytes.4

References/Citations:

  1. Tosi et al. (2021), Superior Properties of N-Acetylcyteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage; Int. J. Mol. Sci. 22 600
  2. Giustarini et al. (2018), N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs; Free Radic. Biol. Med. 126 202
  3. Giustarini et al. (2012), N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential; Biochem. Pharmacol. 84 1522
  4. Steenvoorden et al. (1997), Cysteine derivatives protect against UV-inducede reactive intermediates in human keratinocytes: the role of glutathione synthesis; Photochem. Photobiol. 66 665