N-Eicosanoyl serotonin | Neuroprotective
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $180.00 |
N-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1 It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease.2,3
References/Citations:
1) Yan et al. (2018), Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB; Proc. Natl. Acad. Sci. USA, 115 E12053
2) Asam et al. (2017), Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid; PLoS One, 12 e0189413
3) Basurto-Islas et al. (2014), Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease; Neurobiol. Aging, 35 2701
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
N-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1 It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease.2,3
References/Citations:
1) Yan et al. (2018), Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB; Proc. Natl. Acad. Sci. USA, 115 E12053
2) Asam et al. (2017), Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid; PLoS One, 12 e0189413
3) Basurto-Islas et al. (2014), Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease; Neurobiol. Aging, 35 2701
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