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N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration

N-Oleoylphenylalanine is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration and is the most potent in the group of structurally different lipoamino acids evaluated. Mice treated with an analog, C18-1-Leu, were found to have improved glucose homeostasis and increased energy expenditure.1

References/Citations

1) Long et al. (2016), The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria; Cell, 166 424

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N-Oleoylphenylalanine | Structure | Supplier

Catalog#  10-1602-0005

$50.00
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Catalog Number:
10-1602
Activity:
Endogenous Uncoupler of Mitochondrial Respiration
Chemical Name:
N-Oleoyl Phe
Alternate Names:
NOPA, C18-1-Phe
Molecular Weight:
429.64
Molecular Formula:
C27H43NO3
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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