N-Oleoylphenylalanine is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration and is the most potent in the group of structurally different lipoamino acids evaluated. Mice treated with an analog, C18-1-Leu, were found to have improved glucose homeostasis and increased energy expenditure.1
References/Citations
1) Long et al. (2016), The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria; Cell, 166 424
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