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Product Details

NAcM-OPT | NEDD8 ligation inhibitor

NAcM-OPT is a potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1  It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1


1) Scott et al. (2017), Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase; Nat. Chem. Biol., 13 850
2) Scott et al. (2011), N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex; Science, 334 674

Focus Biomolecules cell signaling supplier, chemical structure of NAcM-OPT | NEDD8 ligation inhibitor | CAS 2089293-61-6

Catalog#  10-1636-0005

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Catalog Number:
NEDD8 ligation inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
98% by HPLC/TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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