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Product Details

NE-100 | Selective sigma-1 antagonist

NE-100 (149409-57-4) is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50 = 1.5 nM) over sigma-2 (IC50 = 85 nM).1,2 NE-100 suppressed ischemia-induced neuronal cell death in mice via upregulation of GPR78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma 1 independent manner.3

References/Citations

1) Okuyama et al. (1994), NE-100, a novel sigma receptor ligand: in vivo tests; Life Sci. 53 PL285
2) Chaki et al. (1994), NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain; Eur. J. Pharmacol. 251 R1
3) Ono et al. (2013), A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells; Biochem. Biophys. Res. Commun. 434 904

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Catalog#  10-4200-0005

$70.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
149409-57-4
Catalog Number:
10-4200
Activity:
Selective sigma-1 antagonist
Chemical Name:
4-Methoxy-3-(2-phenylethoxy)-N,N,dipropylbenzeneethanamine hydrochloride
Molecular Weight:
391.97
Molecular Formula:
C23H33NO2 • HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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