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Nelfinavir mesylate | HIV protease inhibitor / Anticancer activity

Nelfinavir mesylate (159989-65-8) is a clinically useful anti-HIV agent acting via inhibition of HIV-1 protease (Ki=2 nM).1 It also displays efficacy in cancer, malaria, tuberculosis and SARS.2 Displays broad spectrum anticancer activity and induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo.3 Inhibits the growth of HER2-positive breast cancer cells via inhibition of HSP90 through a novel mechanism.4

References/Citations
1) Olmo et al. (2006), A review of nelfinavir for the treatment of HIV infection; Expert Opin. Drug Metab. Toxicol., 2 285
2) Bruning et al. (2010), New prospects for nelfinavir in non-HIV-related diseases; Curr. Mol. Pharmacol., 3 91
3) Gills et al. (2007), Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo; Clin. Cancer Res, 13 5183
4) Shim et al. (2012), Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir; J. Natl. Cancer Inst,, 104 1576

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Catalog#  10-3050

$50.00
Quantity
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CAS:
159989-65-8
Catalog Number:
10-3050
Activity:
HIV protease inhibtior / Anticancer activity
Chemical Name:
(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
Alternate Name:
AG-1343
Molecular Weight:
663.88
Molecular Formula:
C32H45N3O4S • CH3SO3H
Solubility:
Soluble in DMSO (up to 70 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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