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Neurodegeneration

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  • Focus Biomolecules supplier, structure of 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite | CAS 474-73-7
    $50.00
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

  • Focus Biomolecules supplier, chemical structure of 27-Hydroxycholesterol | Cholesterol oxidation metabolite | CAS 20380-11-4
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

  • Focus Biomolecules supplier, chemical structure of ABT-418 HCl | Nicotinic acetylcholine receptor agonist | CAS 147388-83-8
    $90.00
    ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1...

  • Anle138b | Protein aggregation inhibitor
    $55.00
    Anle138b is an aggregation inhibitor that modulates the formation of pathological oligomers of both prion and α-synuclein.1 In mouse models of prion diseases and Parkinson’s disease, Anle138b strongly inhibited...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Apomorphine HCl | Dopamine agonist | CAS 41372-20-7
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure AR-A 014418 | GSK-3 inhibitor | CAS 487021-52-3
    $65.00
    AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable...

  • Auraptene | Neuroprotective / Neuritogenic agent
    $30.00
    Auraptene (495-02-3) is a bioactive terpenoid occurring in a variety of citrus fruits and possessing therapeutic potential.1   Displays neuritogenic activity2 and neuroprotective effects via suppression of...

  • AX-024 | Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation
    $90.00
    AX-024 (1704801-24-0) is a potent (IC50 ~ 1 nM) and specific inhibitor of T cell antigen receptor (TCR)-dependent T cell activation. It inhibited neither B cell proliferation triggered by B cell antigen receptor (BCR), TLR4,...

  • Focus Biomolecules supplier, chemical structure of Benztropine mesylate | Induces remyelination of neurons | CAS 132-17-2
    $38.00
    Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Compound 115-7c | HSP70 modulator | CAS 908074-72-6
    $90.00
    Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cycloheximide-N-ethylethanoate | FKBP12 inhibitor
    $65.00
    FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).1 Mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CZC-54252 | LRRK2 | CAS 1191911-27-9
    $85.00
    CZC-54252 (1191911-27-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. CZC-54252 attenuates the neuronal damage...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DAPT | gamma-secretase inhibitor | CAS 208255-80-5
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • Deferiprone | Iron Chelator
    $20.00
    Deferiprone (30652-11-0) is a clinically useful iron chelator.1 It attenuated blood-brain-barrier breakdown and brain mitochondrial dysfunction in rats with chronic iron-overload.2 Iron chelation therapy has been suggested...

  • Deprenyl | Neuroprotective
    $35.00
    Deprenyl (14611-52-0) potent inhibitor of monoamine oxidase B (MAO- B) which has been used for the treatment of Parkinson’s disease.1,2 Displays neuroprotective effects rescuing nigral dopaminergic neurons after...

  • Focus Biomolecules supplier, chemical structure of Entacapone | COMT inhibitor - anti-Parkinsons | CAS 130929-57-6
    $40.00
    Entacapone (130929-57-6) is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Fasudil HCl | ROCK inhibitor | CAS 105628-07-7
    $45.00
    Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Filipin III | Cholesterol probe | CAS 480-49-9
    $120.00
    Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used...

  • Focus Biomolecules cell signaling supplier, chemical structure of FPS-ZM1 | RAGE receptor antagonist | CAS 945714-67-0
    $55.00
    FPS-ZM1 (945714-67-0) is a high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (IC50 = 0.6 μM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple...

  • Focus Biomolecules reagent supplier, chemical structure of Gabapentin lactam | Neuroprotective agent | CAS 64744-50-9
    $58.00
    Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic...

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