RECTAS | pre-mRNA splicing modulator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $220.00 |
RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells from patients with familial dysautonomia. RECTAS (2 mM) increased the expression of IKAP and restored tRNA modifications.1,2 It directly interacts with CDC-like kinases enhancing SRSF6 phosphorylation.2 A combination treatment with RECTAS and phenylbutyric acid was shown to restore DJ-1 protein and mitochondrial dysfunction in Parkinson’s disease models.3
References/Citations:
- Yoshida et al. (2015), Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia; Proc. Natl. Acad. Sci. USA 112 2764
- Ajiro et al. (2021), Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia; Nat. Commun. 12 4507
- Boussaad et al. (2020), A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease; Sci. Transl. Med. 12 eaau3960
C10H8ClN5O
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells from patients with familial dysautonomia. RECTAS (2 mM) increased the expression of IKAP and restored tRNA modifications.1,2 It directly interacts with CDC-like kinases enhancing SRSF6 phosphorylation.2 A combination treatment with RECTAS and phenylbutyric acid was shown to restore DJ-1 protein and mitochondrial dysfunction in Parkinson’s disease models.3
References/Citations:
- Yoshida et al. (2015), Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia; Proc. Natl. Acad. Sci. USA 112 2764
- Ajiro et al. (2021), Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia; Nat. Commun. 12 4507
- Boussaad et al. (2020), A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease; Sci. Transl. Med. 12 eaau3960
Related products
-
AZD7762 | Checkpoint kinase 1/2 inhibitor
From $60.00CAS:860352-01-8 (free base)Catalog Number:10-4771Activity:Checkpoint kinase 1/2 inhibitorChemical Name:3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide hydrochlorideMolecular Weight:398.88Molecular Formula:C17H19FN4O2S • HClSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Yellow or brown solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling
From $55.00Catalog Number:10-3756Activity:NOTUM inhibitor, restores Wnt signalingChemical Name:N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamideMolecular Weight:292.33Molecular Formula:C18H16N2O2Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20° (des.)Stability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
SNS-314 mesylate | Aurora kinase inhibitor
From $70.00CAS:1146618-41-8Catalog Number:10-4779Activity:Aurora kinase inhibitorChemical Name:1-(3-Chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea mesylateMolecular Weight:527.04Molecular Formula:C18H15ClN6OS2 • CH3SO3HSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.