New DUB inhibitor: Deubiquitinating enzymes, or DUBs, are proteases that regulate ubiquitination dynamics. DUBs have become promising targets for drug discovery across diverse therapeutic areas. For a review see Schauer et al.
Recently Zhang and coworkers reported the identification of OTUDin3 as a potent inhibitor of OTUD3, a DUB that promotes lung tumorigenesis by stabilizing oncoprotein GRP78. OTUDin3 displayed pronounced antiproliferative effects and suppressed the growth of lung cancer xenografts in mice.
Focus Biomolecules offers OTUDin3 in addition to other DUB inhibitors.
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