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4-Bromo-A23187 | Non-fluorescent calcium ionophore

CAS:
76455-48-6
Catalog Number:
10-5590
Activity:
Non-fluorescent calcium ionophore
Chemical Names:
4-Bromocalcimycin
Alternate Name:
4-Bromo-calcium ionophore A23187
Molecular Weight:
602.53
Molecular Formula:
C29H36BrN3O6
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

4-Bromo-A23187 (76455-48-6) is a non-fluorescent analog1 of calcium ionophore A-231872 which may be used in experiments employing fluorescent probes to avoid interference3,4. Off-target effects include uncoupling of oxidative phosphorylation5 and inhibition of SR Ca2+-ATPase6.

References/Citations:

  1. Deber et al. (1985) Bromo-A23187: A nonfluorescent calcium ionophore for use with fluorescent probes; Anal. Biochem. 146 349
  2. Reed and Lardy (1972) A23187: a divalent cation ionophore; J.  Biol. Chem. 247 6970
  3. Wesseling et al. (2016) Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age; Cell Physiol. Biochem. 38 1376
  4. Yang et al. (2013) NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells; J. Biol. Chem. 288 16960
  5. Wong et al. (1973) Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria; Arch.  Biochem. Biophys. 156 578
  6. Hara and Kanazawa (1986) Selective inhibition by ionophore A23187 of the enzyme isomerization in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase; J.  Biol. Chem. 261 16584
4-Bromo-A23187 | Non-fluorescent calcium ionophore is also available in the Cellular Metabolism Library.
CAS:
76455-48-6
Catalog Number:
10-5590
Activity:
Non-fluorescent calcium ionophore
Chemical Names:
4-Bromocalcimycin
Alternate Name:
4-Bromo-calcium ionophore A23187
Molecular Weight:
602.53
Molecular Formula:
C29H36BrN3O6
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

N/A
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