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Honokiol | SIRT3 activator

CAS:
35354-74-6
Catalog Number:
10-2311
Activity:
SIRT3 activator
Chemical Names:
3’,5-Diallyl-[1,1’-biphenyl]-2,4’-diol
Alternate Name:
NSC-293100
Molecular Weight:
266.34
Molecular Formula:
C18H18O2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% TLC/GC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4

References/Citations:

  1. Pillai et al. (2015), Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3; Nat. Commun. 6 6656
  2. Kerr et al. (2020), Rescue of myocardial dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol; JCI Insight 5 e140326
  3. Ye et al. (2019), SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus; CNS Neurosci. 25 355
  4. Lee et al. (2022), Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes; Int. J. Mol. Sci. 23 3740
Honokiol | SIRT3 activator is also available in the Cellular Metabolism Library.
CAS:
35354-74-6
Catalog Number:
10-2311
Activity:
SIRT3 activator
Chemical Names:
3’,5-Diallyl-[1,1’-biphenyl]-2,4’-diol
Alternate Name:
NSC-293100
Molecular Weight:
266.34
Molecular Formula:
C18H18O2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% TLC/GC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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