Luminespib | HSP90 inhibitor

Luminespib (747412-493) is a potent inhibitor (IC50 = 21 nM) of HSP90.1 It is active against various human tumor xenograft models acting via several processes including cytostasis, apoptosis, invasion, and angiogenesis.2,3 Luminespib enhances tumor susceptibility to T-cell-based immunotherapy by re-invigorating the cancer-immunity cycle in NANOG+ cancer cells.4 It also acts as a radiosensitizer against various tumor cells.5-7

References/Citations:

  1. Brough et al. (2008), 4,5-Diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer; Med. Chem. 51 196
  2. Eccles et al. (2008), NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis; Cancer Res. 68 2850
  3. Massey et al. (2010), Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor; Cancer Ther. 5 1807
  4. Song et al. (2020), HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors; Commun. 11 562
  5. Schwab and Multhoff (2022), A Low Membrane Hsp70 Expression in Tumor Cells With Impaired Lactate Metabolism Mediates Radiosensitization by NVP-AUY922; Oncol. 12 861266
  6. Djuzenova et al. (2012), Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cells lines under hypoxia; Cancer Biol. Ther. 13 425
  7. Schilling et al. (2015), Sensitizing tumor cells to radiation by targeting the heat shock response; Cancer Lett. 360 294
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

5 mg, 25 mg

Reviews

There are no reviews yet.

Be the first to review “Luminespib | HSP90 inhibitor”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
747412-49-3
Catalog Number:
10-4672
Activity:
HSP90 inhibitor
Chemical Names:
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Alternate Name:
NVP-AUY922; VER-52296
Molecular Weight:
465.54
Molecular Formula:
C26H31N3O5
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Luminespib | HSP90 inhibitor

$45.00$145.00

CAS:
747412-49-3
Catalog Number:
10-4672
Activity:
HSP90 inhibitor
Chemical Names:
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Alternate Name:
NVP-AUY922; VER-52296
Molecular Weight:
465.54
Molecular Formula:
C26H31N3O5
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

United Kingdom

Tebu-bio UK & Ireland
Unit 7 - Flag Business Exchange
Vicarage Farm Road
Peterborough
Cambs PE1 5TX
England

Phone: +44 (0)1733 421880
Fax: +44 (0)1733 421882
www.tebu-bio.com

2B Scientific
Cherwell Innovation Centre
77 Heyford Park
Upper Heyford
OX25 5HD
UK

Phone: +44(0) 1869 238033
Fax: +44(0) 1869 238034
E-mail: info@2BScientific.com
sales@2BScientific.com
www.2BScientific.com

Germany

Tebu-bio GmbH
Berliner Str. 255
D-63067 Offenbach

Tel: (069) 801013-0
Fax: (069) 801013-20
www.tebu-bio.com

BIOZOL Diagnostica Vertrieb GmbH
Obere Hauptstrasse 10b
85386 Eching

Tel: +498937996666
E-mail: info@biozol.de
www.biozol.de

Biotrend Germany
Wilhelm-Mauser-Str. 41-43
50827 Köln
Tel: +49 221 9498320
Fax: +49 221 9498325
Email:  info @biotrend.com
www.biotrend.com

Portugal

Tebu-bio Portugal
Quinta da Fonte
Rua dos Malhões
Edifício D. Pedro I
2770-071 Paco D'Arcos

Phone: 21 000 82 48
Fax: 21 000 16 75
www.tebu-bio.com

Fax: (069) 801013-20
www.tebu-bio.com

Switzerland

LucernaChem Ag
Abendweg 18
CH-6006 Luzern
Switzerland

Phone: +41 (0)41 420 9636
Fax: +41 (0)41 420 9656
E-mail: lucerna-chem@lucerna-chem.ch
www.lucerna-chem.ch

Anawa
Unterdorfstrasse 21
CH-8602 Wangen
Switzerland

Phone: +41 (0)44 805 76 81
Fax: +41 (0)44 805 76 75
E-mail: contactus@anawa.ch
www.anawa.ch

Belgium

Tebu-bio
tebu-bio Belgium
Alexander Franckstraat 196
B-2530 Boechout

Phone: 03/ 454 00 66
Fax: 03/ 454 18 88
www.tebu-bio.com

Austria

Biomedica Medizinprodukte gmbH & Co KG
Divischgasse 4
1210 Vienna
Austria

Phone: +43 1 291 07 0
Fax: +43 1 290 14 29
Email: office@bmgrp.at
www.bmgrp.at

Biotrend Austria
Sternwartwatrasse 76
A-1180 Wien
Austria

Phone: +43 7201 15577
Fax: +43 7201 15580
Email:info@biotrend.com
www.biotrend.com

Bulgaria

Biomedica Bulgaria Ltd.
2E "Akad. Ivan E. Geshov" blvd.
Business center "Serdika" build. 2, floor 2, office 203
Sofia 1330
Bulgaria

Phone: +359 2 447 2833
Fax: +359 2 447 2831
Email: office@bmgrp.bg
www.bmgrp.bg

Czech Republic

Biomedica CS, s.r.o.
Sokolovska 100/94, Meteor B
186 00 Praha 8 - Karlin
Czech Republic

Phone: +420 2 839 33 605
Fax: +420 2 839 32 507
Email: office@bmgrp.cz
www.bmgrp.cz

Macedonia

Biomedica dijagnostika Ltd.
Ul. Ilindenska br. 103 lokal 2 and 3
1000 Skopje
Macedonia

Phone: +389 232 22 404
Fax: +389 232 22 404
Email: office@bmgrp.mk
www.bmgrp.mk

Romania

Biomedica Medizinprodukte Romania SRL
Strada Siriului nr. 42-46, Et.2, Sector 1
014354 Bucharest
Romania

Phone: +40 37 276 68 44
Fax: +40 21 232 22 04
Email: office@bmgrp.ro
www.bmgrp.ro

France

Tebu-bio France
39 Rue de Houdan - BP 15
78612 Le Perray-en-Yvelines Cedex

Phone: 01 30 46 39 00
Fax: 01 30 46 39 11
www.tebu-bio.com

CliniSciences France
74 Rue des Suisses
92000 Nanterre

Phone: +33 9 77 40 09 09
Fax: +33 9 77 40 10 11
info@clinisciences.com
www.clinisciences.com

Spain

Tebu-bio Spain
Gran Via de les Corts Catalanes, 583-5°
ES-08011 Barcelona

Phone: 93 306 34 10
Fax: 93 306 34 99
www.tebu-bio.com

Italy

DBA Italia
Via Umbria, 10
20090 Segrate (Milan)
Italy

Phone: +39 02 26922300
Fax: +39 02 26923535
E-mail: info@dbaitalia.it
www.dbaitalia.it

Tebu-bio Italy
Via Pretorio 4 - C.P. 70
I-20013 Magenta MI

Phone: 02 97 20 50 10
Fax: 02 97 29 50 77

Clinisciences Italy
Via Maremmana Inferiore 378
00012 Guidonia Montecelio (Roma)

Phone: +39 06 94 80 56 71
Fax: +39 06 94 80 00 21
Italia@clinisciences.com
www.clinisciences.com

Denmark

Tebu-bio Nordic Countries

CAT Science Park
Universitetsparken 7
4000 Roskilde
Denmark

Phone: +45 46 74 02 54
Fax: +45 46 74 02 53
www.tebu-bio.com


CliniSciences Denmark

Herlev Hovedgade 195
2730 Herlev

Phone: +45 89 888 349
Fax: +45 89 884 064
danmark@clinisciences.com
www.clinisciences.com

Sweden

Tebu-bio Netherlands  
Bevelandseweg 80
NL-1703 AX Heerhugowaard

Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com

Finland

Tebu-bio Netherlands  
Bevelandseweg 80
NL-1703 AX Heerhugowaard

Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com

Netherlands

Tebu-bio Netherlands  
Bevelandseweg 80
NL-1703 AX Heerhugowaard

Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com

Bosnia-Herzegovina

Biomedica d.o.o
Dr. Silve Rizvanbegovic bb
71210 Ilidza, Sarajevo
Bosnia and Herzegovina

Phone: +387 33 262 725
Fax: 387 33 262 726
Email: office@bmgrp.ba
www.bmgrp.ba

Croatia

Biomedica Dijagnostika d.o.o.
Strojarska 20/X
10000 Zagreb
Croatia

Phone: +385 1 888 5727
Fax: +385 1 888 5728
Email: office@bmgrp.hr
www.bmgrp.hr

Hungary

Biomedica Hungaria Kft.
Ganz u. 16
1027 Budapest
Hungary

Phone: +361 225 38 50
Fax: +361 201 26 84
Email: office@bmgrp.hu
www.bmgrp.hu

Poland

Biomedica Poland sp. z.o.o.
Ul. Raszynska 13
05-500 Piaseczno
Poland

Phone: +48 22 737 5996
Fax: +48 22 737 5994
Email: office@bmgrp.pl
www.bmgrp.pl

Serbia

Biomedica MP d.o.o.  
Lazara Mamuzica 26a
11186 Zemun
Serbia

Phone: +381 11 630 1882
Fax: +381 11 630 1883
Email: office@bmgrp.rs
www.bmgrp.rs

Slovenia

Biomedica M.B. d.o.o.  
Slokanova 12
2000 Maribor
Slovenia

Phone: +386 2 471 63 01
Fax: +386 2 471 63 04
Email: office@bmgrp.si
www.bmgrp.si

Slovakia

Biomedica Slovakia s.r.o.
Drobneho 27
84101 Bratislava
Slovakia

Phone: +421 2 693 099 01
Fax: +421 2 693 099 08
Email: office@bmgrp.sk
www.bmgrp.sk

®Copyright 2021 Focus Biomolecules. All Rights Reserved. Site by A.N. Creative